Coagulation activation during air travel is not initiated via the extrinsic pathway
نویسندگان
چکیده
منابع مشابه
Fluid loss does not explain coagulation activation during air travel.
The mechanism of air travel-related venous thrombosis is unclear. Although immobility plays a pivotal role, other factors such as fluid loss may contribute. We investigated whether fluid loss occurred more in individuals with coagulation activation after air travel than in subjects without. As a secondary aim, we investigated whether fluid loss per se occurred during air travel. In this crossov...
متن کاملActivation of coagulation system during air travel: a crossover study.
BACKGROUND There is an increased risk of venous thrombosis after air travel, but the underlying mechanism is unclear. Our aim was to ascertain whether flying leads to a hypercoagulable state. METHODS We did a crossover study in 71 healthy volunteers (15 men, 56 women), in whom we measured markers of activation of coagulation and fibrinolysis before, during, and after an 8-h flight. The same i...
متن کاملUniversity of Groningen Coagulation factor VIIa : prohemostatic drug and biomarker for thrombosis
Background: While air travel is a well-established risk factor for venous thrombosis, the underlying mechanism is still incompletely understood. We previously demonstrated coagulation activation during air travel in healthy individuals, as assessed by a rise in thrombin-antithrombin complexes. It has been suggested that venous thrombosis is initiated via the extrinsic pathway of coagulation, sp...
متن کاملEffect of hypobaric hypoxia, simulating conditions during long-haul air travel, on coagulation, fibrinolysis, platelet function, and endothelial activation.
CONTEXT The link between long-haul air travel and venous thromboembolism is the subject of continuing debate. It remains unclear whether the reduced cabin pressure and oxygen tension in the airplane cabin create an increased risk compared with seated immobility at ground level. OBJECTIVE To determine whether hypobaric hypoxia, which may be encountered during air travel, activates hemostasis. ...
متن کاملAn alternative extrinsic pathway of human blood coagulation.
To study the interrelationships of the major human coagulation pathways, factor X activation in normal and various deficient human plasmas was evaluated when clotting was triggered by dilute rabbit or human thromboplastin. Various dilutions of thromboplastin were added to plasma samples containing 3H-labeled factor X, and the time course of factor X activation was determined. At a 1/250 dilutio...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2014
ISSN: 0007-1048
DOI: 10.1111/bjh.13257